日本語
NIHON UNIVERSITY's 
College of Engineering 
Department of Chemical Biology and Applied Chemistry 

Updated : 2019/06/27 
Professor 
HARUKI Mitsuru 

My website is here.  

Career (Number of the published data : 8)
Protein Engineering Research Institute  第4研究部  Research Scientist  1991/04-1995/06 
Osaka University  Department of Msterial and life Science, Graduate School of Engieering  Reserch Assistant  1995/07-2002/03 
Nihon University  Departmrnt of Materials Chemistry and Engineering, College of Engineeering  Associate Professor  2002/04-2007/03 
Nihon University  Departmrnt of Materials Chemistry and Engineering, College of Engineeering  Associate Professor  2007/04/01-2010/03/31 
National Institutes of Health  National Institute of Child Health and Human Development  Guest Researcher, National Institutes of Health  2008/04/01-2009/03/22 
Nihon University  Department of Chemical Biology and Applied Chemistry  Professor  2010/04/01-Present 
大阪大学   大学院工学研究科  非常勤講師  2013/10/01-2014/03/31 
富山大学  和漢医薬学総合研究所  協力研究員  2016-2018/03/31 

Academic background (Number of the published data : 1)
The University of Tokyo  Graduate School, Division of Science  生物化学  1991  Completed 

Academic degrees (Number of the published data : 1)
Doctor(Science)  The University of Tokyo 

Licenses and qualifications (Number of the published data : 1)
第1種放射線取扱主任者  1999/10/29 

Research Areas (Number of the published data : 3)
Living Organism Molecular Science 
Chemistry Related to Living Body 
Bio-Function/Bioprocesses 

Research keywords (Number of the published data : 17)
Selection Technology 
Molecular Recognition 
Protein Engineering 
Protein 
Selection 
Random Mutation 
Hyperthermophilic Enzyme 
Psychlophilic Enzyme 
Proteomic Analysis 
Aquatic Organic Reaction 
Ester Synthesis 
Peptide Synthesis 
Recombinant DNA Experiment 
Heat-inactivatable Enzymes 
Psychrophilic Enzymes 
Molecularly imprinted polymer- 
refolding of proteins 

Subject of research (Number of the published data : 5)
Study on Protein Function and structure using Selection Technology  1991-Present 
Study on Adaptation Mechanism of Hyperthermophile and Psychlophile to Extreme Temperature  1996-Present 
Development of detergent-unified enzymes for aquatic organic reaction  2002-2004 
Development of heat-inactivatable and psychrophilic enzymes supporting green and efficient processes of recombinant DNA experiment  2002-2004 
Molecularly imprinted polymer-assisted refolding of proteins  2005-Present 
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Proposed theme of joint or funded research (Number of the published data : 2)
Development of Enzyme Inhibitors by Phage Display Technique 
Alteration of Enzyme Function by Random Mutation 
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Achievements of joint or funded research (Number of the published data : 3)
癌に普遍的に効果のある薬剤の開発を目指したMTH1活性阻害作用およびRcn1/DSCR1の分解阻害作用を示す生薬のスクリーニング  2016-Present 
非天然型アミノ酸を導入したタンパク質の耐熱化機構の解明  2012-Present 
熱風利用による有機物高度堆肥化技術及び二次生産物の高度活用技術の開発  2010-2011 
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Bibliography (Number of the published data : 12)
ロハス工学  日経BP社  2019/02/25 
タンパク質結晶の新展開  シーエムシー出版  2008 
ゲノム化学  化学同人  2007/03/31 
バイオプロセスハンドブック  エヌ・ティー・エス  2007/03/23 
酵素開発・利用の最新技術  シーエムシー出版  2006/12/28 
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Papers (Number of the published data : 81)
Alkyne-functionalized cationic polysiloxane polymers conjugated with targeting molecules by click reactions for DNA delivery  Journal of Nanoscience and Nanotechnology  2017 
Synthesis of alkyne-functionalized amphiphilic polysiloxane polymers and formation of nanoemulsions conjugated with bioactive molecules by click reactions  Polymer Journal  2014/03 
Enhancement of the enzymatic activity of Escherichia coli acetyl esterase by random mutagenesis  Journal of Molecular Catalysis B: Enzymatic  2010/11 
A Novel Strategy for Stabilization of Escherichia coli Ribonuclease HI Involving a Screen for an Intragenic Suppressor of Carboxyl-terminal Deletions  Journal of Biological Chemistry  1994 
Stabilization of E. coli Ribonuclease HI by the ‘stability profile of mutant protein’ (SPMP)-inspired random and non-random mutagenesis  Journal of Biotechnology  2006/07/25 
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Research presentations (Number of the published data : 240)
Oral presentation(general)  好熱嫌気性細菌Clostridium thermocellum由来セルロソーム構成セルラーゼの結晶性セルロース分解に対する相乗効果  2018年度日本農芸化学会大会  2019/03/27 
Oral presentation(general)  RNase H を利用したmRNAの増幅的検出法の開発  第61回日本大学学術研究報告会  2018/12/08 
Poster presentation  Amplification of RNA signal by iterated target-induced cleavage of fluorescent probes by intracellular RNase H activity conjugated with amyloid-β peptides  平成30年度化学系学協会東北大会  2018/09/16 
Poster presentation  Detection of amyloid-β peptides using colloidal gold particles formed by sulfhydrylated polysiloxane polymers conjugated with amyloid-β peptides  平成30年度化学系学協会東北大会  2018/09/16 
Poster presentation  Suppression of epithelial sodium channel gene expression by polyphenols  平成30年度化学系学協会東北大会  2018/09/15 
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Intellectual property rights (Number of the published data : 5)
Patent  Shewanellasp.SIB1株由来の新規なアルカリフォスファターゼ 
Patent  耐熱性リボヌクレアーゼH及びそれをコードするDNA 
Patent  大腸菌リボヌクレアーゼHIに結合するペプチド 
Patent  5重置換による大腸菌リボヌクレアーゼHIの安定化 
Patent  変異型大腸菌リボヌクレアーゼHI 
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Prizes (Number of the published data : 1)
社団法人新化学発展協会研究奨励金  2002/06/05  Domestic 
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Research expenses (Number of the published data : 15)
Grant-in-Aid for Scientific Research  RNase H を利用したmRNAの増幅的検出法の開発と薬剤スクリーニングへの応用  2017-2019 
Other  福島県発の災害に強く自立可能な住環境の創成に関する研究  2012-2014 
Sponsored research  熱風利用による有機物高度堆肥化技術及び二次生産物の高度活用技術の開発  2010-2011 
In school research expenses  ロハスを指向したバイオエネルギー生産と健康に役立つ分子の開発  2010-2010 
Other grant  グローバルネットワークによる次世代医療機器開発とバイオメディカル工学研究拠点形成  2009-2013 
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Alloted class (Number of the published data : 10)
化学I 
生物学実験 
生命分子工学特論 
化学実験及び演習 
ロハス工学特論I 
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Teaching achievements (Number of the published data : 2)
日大工における化学教育事例を私立大学化学系教員連絡協議会シンポジウムにおいて発表  2015/10-2015/10 
日大工における化学教育事例を私立大学化学系教員連絡協議会シンポジウムにおいて発表  2014/10-2014/10 
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Social activities (Number of the published data : 12)
夢発見サイエンスツアー 体験コース担当  2016/03/30-2016/03/30 
夢発見サイエンスツアー 体験コース担当  2015/03/30-2015/03/30 
日本化学会「夢化学21〜化学への招待」講師  2013/07/27-2013/07/27 
日本化学会「夢化学21〜化学への招待」講師  2009/08/01-2009/08/01 
(財)郡山地域テクノポリス推進機構技術アドバイザー  2009/04-2014/03 
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Memberships of academic societies (Number of the published data : 8)
日本化学会 
日本生化学会 
日本生物工学会 
日本農芸化学会  2012/09-Present 
日本蛋白科学会 
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