Papers
Number of the published data : 58

No.1
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Alkyne-functionalized cationic polysiloxane polymers conjugated with targeting molecules by click reactions for DNA delivery
Author Kihara Y, Maeda R, Imaizumi A, Ichikawa T, Nemoto N, Ishihara T, Hirano N, and Haruki M
Journal J. Nanosci. Nanotech.
Publisher
Volume/issue/page 17, 5081-5089
Publication date 2017
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No.2
Publishing type Research paper (scientific journal)
Authorship Joint work
Title Development of liver-specific ribavirin-loaded nanoparticles with reduced cytotoxicity
Author Kaneko K, Ishihara T
Journal Cogent Medicine
Publisher
Volume/issue/page 4/ 1, 1418133
Publication date 2017/12
ISSN
DOI 10.1080/2331205X.2017.1418133
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No.3
Publishing type Research paper (scientific journal)
Authorship Joint work
Title Scavenging of superoxide anions by lecithinized superoxide dismutase in HL-60 cells
Author Ishihara T, Shibui M, Hoshi T, Mizushima T
Journal Molecular BioSystems
Publisher
Volume/issue/page 12, 274-282
Publication date 2016
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No.4
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Encapsulation of beraprost sodium in nanoparticles: Analysis of sustained release properties, targeting abilities and pharmacological activities in animal models of pulmonary arterial hypertension.
Author Ishihara T, Hayashi E, Yamamoto S, Kobayashi C, Tamura Y, Sawazaki R, Tamura F, Tahara K, Kasahara T, Ishihara T, Takenaga M, Fukuda K, Mizushima T.
Journal J Control. Release
Publisher
Volume/issue/page 197, 97-104
Publication date 2015
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No.5
Publishing type Research paper (scientific journal)
Authorship Joint work
Title Development of biodegradable nanoparticles for liver-specific ribavirin delivery
Author Tsutomu Ishihara, Kohei Kaneko, Tomoaki Ishihara, Tohru Mizushima
Journal J Pharm Sci.
Publisher
Volume/issue/page 103/ 12, 4005-4011
Publication date 2014/12
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No.6
Publishing type Research paper (scientific journal)
Authorship Joint work
Title Interactions of Lecithinized Superoxide Dismutase with Serum Proteins and Cells
Author Ishihara T, Nara S, Mizushima T
Journal J Pharm Sci.
Publisher
Volume/issue/page 103, 1987-1994
Publication date 2014/05
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No.7
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Prostaglandin E1-encapsulated nanoparticles improve walking activity in an experimental rat model of intermittent claudication
Author Ishihara T, Yamashita Y, Takasaki N, Yamamoto S, Hayashi E, Tahara K, Takenaga M, Yamakawa N, Ishihara T, Kasahara T, Mizushima T.
Journal Journal of Pharmacy and Pharmacology
Publisher
Volume/issue/page 65/ 8, 1187-1194
Publication date 2013/08
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No.8
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Poly (N-isopropylacrylamide)-PLA and PLA blend nanoparticles for temperature-controllable drug release and intracellular uptake.
Author Ayano E, Karaki M, Ishihara T, Kanazawa H, Okano T.
Journal Colloids Surf B Biointerfaces.
Publisher
Volume/issue/page 99, 67-73
Publication date 2012/11
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No.9
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Fluorescent nucleosides with 'on-off' switching function, pH-responsive fluorescent uridine derivatives.
Author Saito Y, Miyamoto S, Suzuki A, Matsumoto K, Ishihara T, Saito I.
Journal Bioorg Med Chem Lett.
Publisher
Volume/issue/page 15/ 22, 2753-2756
Publication date 2012/04
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No.10
Publishing type Research paper (scientific journal)
Authorship Joint work(Leading writer)
Title Nuclear localization and antisense effect of PNA internalized by ASGP-R-mediated endocytosis with protein/DNA conjugates.
Author Ishihara T., Kano A., Obara K., Saito M., Chen X., Park T.G., Akaike T., Maruyama A.
Journal J. Control. Release
Publisher
Volume/issue/page 155, 34-39
Publication date 2011/10
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No.11
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Therapeutic effect of stealth-type polymeric nanoparticles with encapsulated betamethasone phosphate on experimental autoimmune uveoretinitis
Author Sakai T., Ishihara T., Higaki M., Akiyama G., Tsuneoka H.
Journal Invest. Ophthalmol. Vis. Sci.
Publisher
Volume/issue/page 52/ 3, 1516-1521
Publication date 2011/03
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No.12
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Stealth-nanoparticle strategy for enhancing the efficacy of steroids in mice with noise-induced hearing loss
Author Horie R., Sakamoto T., Nakagawa T., Ishihara T., Higaki M., Ito J.
Journal Nanomedicine(Lond)
Publisher
Volume/issue/page 5, 1331-1340
Publication date 2010/11
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No.13
Publishing type Research paper (scientific journal)
Authorship Joint work
Title Evasion of the accelerated blood clearance phenomenon by coating of nanoparticles with various hydrophilic polymers
Author Ishihara T., Maeda T., Sakamoto H., Takasaki N., Shigyo M., Ishida T., Kiwada H., Mizushima Y., Mizushima T.
Journal Biomacromolecules
Publisher
Volume/issue/page 11, 2700-2706
Publication date 2010/08
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No.14
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Nano PGE1 promoted the recovery from spinal cord injury-induced motor dysfunction through its accumulation and sustained release.
Author Takenaga M, Ishihara T, Ohta Y, Tokura Y, Hamaguchi A, Igarashi R, Mizushima T.
Journal J. Control. Release
Publisher
Volume/issue/page 148, 249-254
Publication date 2010/08
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No.15
Publishing type Research paper (scientific journal)
Authorship Joint work
Title Techniques for efficient entrapment of pharmaceuticals in biodegradable solid micro/nanoparticles
Author Ishihara T., Mizushima T.
Journal Expert Opinion on Drug Delivery
Publisher
Volume/issue/page 7/ 5, 565-575
Publication date 2010/05
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No.16
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Therapeutic effect of lecithinized superoxide dismutase on bleomycin-induced pulmonary fibrosis.
Author Tanaka K, Ishihara T, Azuma A, Kudoh S, Ebina M, Nukiwa T, Sugiyama Y, Tasaka Y, Namba T, Ishihara T, Sato K, Mizushima Y, Mizushima T.
Journal Am. J. Physiol. Lung Cell Mol. Physiol.
Publisher
Volume/issue/page 298/ 3, 348-360
Publication date 2010/03
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No.17
Publishing type Research paper (scientific journal)
Authorship Joint work
Title Preparation and characterization of a nanoparticulate formulation composed of PEG-PLA and PLA as anti-inflammatory agents
Author Ishihara T, Takahashi M, Higaki M, Mizushima Y, Mizushima T.
Journal Int. J. Pharm.
Publisher
Volume/issue/page 385/ 1-2, 170-175
Publication date 2010/01/29
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No.18
Publishing type Research paper (scientific journal)
Authorship Joint work(Leading writer)
Title Accelerated blood clearance phenomenon upon repeated injection of PEG-modified PLA-nanoparticles.
Author Ishihara T, Takeda M, Sakamoto H, Kimoto A, Kobayashi C, Takasaki N, Yuki K, Tanaka K, Takenaga M, Igarashi R, Maeda T, Yamakawa N, Okamoto Y, Otsuka M, Ishida T, Kiwada H, Mizushima Y, Mizushima T.
Journal Pharm. Res.
Publisher
Volume/issue/page 26/ 10, 2270-2279
Publication date 2009/10
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No.19
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Effect of betamethasone phosphate loaded polymeric nanoparticles on a murine asthma model.
Author Matsuo Y, Ishihara T, Ishizaki J, Miyamoto K, Higaki M, Yamashita N.
Journal Cell Immunol.
Publisher
Volume/issue/page 260/ 1, 33-38
Publication date 2009/08/04
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No.20
Publishing type Research paper (scientific journal)
Authorship Joint work
Title Efficient entrapment of poorly water-soluble pharmaceuticals in hybrid nanoparticles.
Author Ishihara T, Goto M, Kanazawa H, Higaki M, Mizushima Y.
Journal J. Pharm. Sci.
Publisher
Volume/issue/page 98/ 7, 2357-2363
Publication date 2009/07
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No.21
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Synthesis of prostaglandin E(1) phosphate derivatives and their encapsulation in biodegradable nanoparticles.
Author Takeda M, Maeda T, Ishihara T, Sakamoto H, Yuki K, Takasaki N, Nishimura F, Yamashita T, Tanaka K, Takenaga M, Igarashi R, Higaki M, Yamakawa N, Okamoto Y, Ogawa H, Otsuka M, Mizushima Y, Mizushima T.
Journal Pharm. Res.
Publisher
Volume/issue/page 26/ 7, 1792-1800
Publication date 2009/07
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No.22
Publishing type Research paper (scientific journal)
Authorship Joint work(Leading writer)
Title Polymeric nanoparticles encapsulating betamethasone phosphate with different release profiles and stealthiness.
Author Ishihara T, Kubota T, Choi T, Takahashi M, Ayano E, Kanazawa H, Higaki M.
Journal Int. J. Pharm.
Publisher
Volume/issue/page 375/ 1-2, 148-154
Publication date 2009/06/22
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No.23
Publishing type Research paper (scientific journal)
Authorship Joint work(Leading writer)
Title Treatment of experimental arthritis with stealth-type polymeric nanoparticles encapsulating betamethasone phosphate.
Author Ishihara T, Kubota T, Choi T, Higaki M.
Journal J. Pharmacol. Exp. Ther.
Publisher
Volume/issue/page 329/ 2, 412-417
Publication date 2009/05
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No.24
Publishing type Research paper (scientific journal)
Authorship Joint work
Title Intracellular delivery of siRNA by cell-penetrating peptides modified with cationic oligopeptides.
Author Ishihara T, Goto M, Kodera K, Kanazawa H, Murakami Y, Mizushima Y, Higaki M.
Journal Drug Deliv.
Publisher
Volume/issue/page 16/ 3, 153-159
Publication date 2009/04
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No.25
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Therapeutic effect of lecithinized superoxide dismutase against colitis.
Author Ishihara T, Tanaka K, Tasaka Y, Namba T, Suzuki J, Ishihara T, Okamoto S, Hibi T, Takenaga M, Igarashi R, Sato K, Mizushima Y, Mizushima T.
Journal J. Pharmacol. Exp. Ther.
Publisher
Volume/issue/page 328/ 1, 152-164
Publication date 2009/01
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No.26
Publishing type Research paper (scientific journal)
Authorship Joint work
Title Efficient encapsulation of a water-soluble corticosteroid in biodegradable nanoparticles.
Author Ishihara T, Takahashi M, Higaki M, Mizushima Y.
Journal Int. J. Pharm.
Publisher
Volume/issue/page 365/ 1-2, 200-205
Publication date 2009/01/05
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No.27
Publishing type Research paper (scientific journal)
Authorship Joint work
Title Prolonging the in vivo residence time of prostaglandin E(1) with biodegradable nanoparticles.
Author Ishihara T, Takahashi M, Higaki M, Takenaga M, Mizushima T, Mizushima Y.
Journal Pharm. Res.
Publisher
Volume/issue/page 25/ 7, 1686-1695
Publication date 2008/07
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No.28
Publishing type (MISC) Research paper
Authorship Individual works
Title ステルス型DDS製剤
Author
Journal 炎症と免疫
Publisher
Volume/issue/page 16/ 3, 373-374
Publication date 2008/03
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No.29
Publishing type (MISC) Research paper
Authorship Individual works
Title 高分子ナノ粒子
Author
Journal 炎症と免疫
Publisher
Volume/issue/page 16/ 1, 27-31
Publication date 2008/01
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No.30
Publishing type (MISC) Research paper
Authorship Joint work(Other)
Title 副作用が著しく減少すると考えられる徐放性ステロイド注射剤
Author 水島裕、檜垣恵、石原務
Journal 炎症と免疫
Publisher
Volume/issue/page 15/ 3, 405-408
Publication date 2007/03
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No.31
Publishing type (MISC) Research paper
Authorship Individual works
Title DDSを用いた膠原病の治療-関節リウマチとナノステロイド
Author
Journal 炎症と免疫
Publisher
Volume/issue/page 15/ 2, 209-213
Publication date 2007/02
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DOI
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No.32
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Transdermal delivery of CaCO3-nanoparticles containing insulin.
Author Higaki M, Kameyama M, Udagawa M, Ueno Y, Yamaguchi Y, Igarashi R, Ishihara T, Mizushima Y.
Journal Diabetes Technol Ther.
Publisher
Volume/issue/page 8/ 3, 369-374
Publication date 2006/06
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No.33
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Treatment of experimental autoimmune uveoretinitis with poly(lactic acid) nanoparticles encapsulating betamethasone phosphate.
Author Sakai T, Kohno H, Ishihara T, Higaki M, Saito S, Matsushima M, Mizushima Y, Kitahara K.
Journal Exp. Eye Res.
Publisher
Volume/issue/page 82/ 4, 657-663
Publication date 2006/04
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No.34
Publishing type (MISC) Research paper
Authorship Joint work(Other)
Title ステロイド封入ナノ微粒子
Author 出雲信夫、石原務、水島裕
Journal 日本臨床
Publisher
Volume/issue/page 64/ 2, 329-334
Publication date 2006/02
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No.35
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Injectable porous hydroxyapatite microparticles as a new carrier for protein and lipophilic drugs.
Author Mizushima Y, Ikoma T, Tanaka J, Hoshi K, Ishihara T, Ogawa Y, Ueno A.
Journal J Control Release.
Publisher
Volume/issue/page 110/ 2, 260-265
Publication date 2006/01/10
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DOI
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No.36
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Drug delivery to the cochlea using PLGA nanoparticles.
Author Tamura T, Kita T, Nakagawa T, Endo T, Kim TS, Ishihara T, Mizushima Y, Higaki M, Ito J.
Journal Laryngoscope
Publisher
Volume/issue/page 115/ 11, 2000-2005
Publication date 2005/11
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No.37
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Treatment of experimental arthritis with poly(D,L-lactic/glycolic acid) nanoparticles encapsulating betamethasone sodium phosphate
Author Higaki M., Ishihara T., Izumo N., Takatsu M., Mizushima Y.
Journal Ann. Rheum. Dis.
Publisher
Volume/issue/page 64/ 8, 1132-1136
Publication date 2005/08
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No.38
Publishing type Research paper (scientific journal)
Authorship Joint work
Title Role of zinc in formulation of PLGA/PLA nanoparticles encapsulating betamethasone phosphate and its release profile.
Author Ishihara T, Izumo N, Higaki M, Shimada E, Hagi T, Mine L, Ogawa Y, Mizushima Y.
Journal J Control Release.
Publisher
Volume/issue/page 105/ 1-2, 68-76
Publication date 2005/06/20
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No.39
Publishing type (MISC) Research paper
Authorship Joint work
Title 新しく開発中の薬剤①-ナノステロイド-
Author 石原務、出雲信夫、檜垣恵、水島裕
Journal 炎症と免疫
Publisher
Volume/issue/page 13/ 2, 143-147
Publication date 2005/02
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DOI
URL
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No.40
Publishing type (MISC) Research paper
Authorship Joint work
Title ナノ微粒子製剤の開発とそのDDSへの応用
Author 石原務、出雲信夫、水島裕
Journal Pharm Tech Japan
Publisher
Volume/issue/page 20/ 13, 2621-2627
Publication date 2004/09
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DOI
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No.41
Publishing type (MISC) Research paper
Authorship Joint work(Other)
Title 新規ステロイドDDS製剤PLGA/PLAナノスフェア
Author 出雲信夫、石原務
Journal 医学の歩み
Publisher
Volume/issue/page 209/ 3, 184-185
Publication date 2004/03
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No.42
Publishing type (MISC) Research paper
Authorship Individual works
Title 徐放性ナノ微粒子製剤の開発
Author
Journal Drug Delivery System
Publisher
Volume/issue/page 19/ 2, 136-137
Publication date 2004/02
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No.43
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Polyethyleneimine/arabinogalactan conjugate as a hepatocyte specific gene carrier
Author Nogawa M., Ishihara T., Akaike T., Maruyama A.
Journal S.T.P. Pharma. Sciences
Publisher
Volume/issue/page 11, 97-102
Publication date 2001/01
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No.44
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Receptor-mediated cell modulator delivery to hepatocyte using nanoparticles coated with carbohydrate-carrying polymers
Author Cho C-S., Kobayashi A., Takei R., Ishihara T., Maruyama A., Akaike T.
Journal Biomaterials
Publisher
Volume/issue/page 22, 45-51
Publication date 2001/01
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No.45
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Comb-type cationic copolymer expedites DNA strand exchange while stabilizing DNA duplex
Author Kim W-J., Ishihara T., Akaike T., Maruyama A.
Journal Chemistry
Publisher
Volume/issue/page 5, 176-180
Publication date 2001/01/05
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No.46
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Strand Invasion by Mixed Base PNAs and PNA-Peptide Chimera
Author Zhang X., Ishihara T., Corey D.R.
Journal Nucleic Acid Research
Publisher
Volume/issue/page 28/ 17, 3332-3338
Publication date 2000/09/01
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No.47
Publishing type (MISC) Research paper
Authorship Joint work(Leading writer)
Title 遺伝子デリバリーとバイオマテリアル
Author 石原務、丸山厚、赤池敏宏
Journal Drug Delivery System
Publisher
Volume/issue/page 15/ 2, 106-112
Publication date 2000/02
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No.48
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Reguration of DNA function by cationic graft copolymers.
Author Maruyama A., Kim W-J., Ishihara T., Ueda M., Torigoe H., Ferdous A., Akaike T.
Journal Biomaterials and Drug Delivery toward new mellenium
Publisher
Volume/issue/page 175-181
Publication date 2000/01
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No.49
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Comb-type copolymers for controlled DNA delivery
Author Maruyama A., Ferdous A., Ishihara T., Asayama S., Park J-U., Nogawa M., Watanabe H., Takei Y., Akaike T.
Journal Nucleosides Nucleotides
Publisher
Volume/issue/page 18/ 6-7, 1681-1682
Publication date 1999/06
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No.50
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Design of multi-functional nanopritcles as a DNA carrier
Author Maruyama A., Ishihara T., Kim J-S., Kim S-W., Akaike T.
Journal Colloids and Surfaces A
Publisher
Volume/issue/page 153, 439-443
Publication date 1999/01
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No.51
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Preparation of dendritic graft copolymer consisting of poly(L-lysine) and arabinogaractan as a hepatocyte specific DNA carrier
Author Park J-U., Ishihara T., Kano A., Akaike T., Maruyama A.
Journal Prep. Biochem. Biotech.
Publisher
Volume/issue/page 29, 353-370
Publication date 1999/01
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No.52
Publishing type Research paper (scientific journal)
Authorship Joint work(Leading writer)
Title Rules for strand invasion by chemically modified oligonucleotides
Author Ishihara T., Corey D.R.
Journal J. Am. Chem. Soc.
Publisher
Volume/issue/page 121, 2012-2020
Publication date 1999/01
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No.53
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title A Nanoparticle DNA carrier with Poly(L-lysine) grafted Polysaccharide Copolymer and Poly(D,L-lactic acid)
Author Maruyama A., Ishihara T., Akaike T.
Journal Bioconjugate Chemistry
Publisher
Volume/issue/page 8/ 5, 735-742
Publication date 1998/09
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No.54
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Characterization of inter polyelectrolyte complex between double stranded DNA and polylysine comb-type copolymer having hydrophilic side chains
Author Maruyama A., Watanabe H., Ferdous A., Katoh M., Ishihara T., Akaike T.
Journal Bioconjugate Chemistry
Publisher
Volume/issue/page 9, 292-299
Publication date 1998/01
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No.55
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Simple Preparation of Nanoparticles coated with carbohydrate-carrying Polymers
Author Cho C-S., Jeong Y-I., Ishihara T., Takei R., Park J-U., Park K-H., Maruyama A., Akaike T.
Journal Biomaterials
Publisher
Volume/issue/page 18, 323-326
Publication date 1997/02
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No.56
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Comb-Type Polycations Effectively stabilize DNA Triplex
Author Maruyama A., Katoh M., Ishihara T., Akaike T.
Journal Bioconjugate Chemistry
Publisher
Volume/issue/page 8/ 1, 3-6
Publication date 1997/01
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No.57
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Preparation of Nanoparticles Bearing High Density of Carbohydrate Chains Using Carbohydrate Carrying Polymers as an Emulsifier
Author Maruyama, A. Ishihara T., Adachi N., Akaike T.
Journal Biomaterials
Publisher
Volume/issue/page 15/ 13, 1035-1042
Publication date 1994/10
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No.58
Publishing type Research paper (scientific journal)
Authorship Joint work(Other)
Title Cellular Distribution of Polymer Particles bearing various densities of carbohydrate ligands
Author Adachi N., Maruyama A., Ishihara T., Akaike T.
Journal J. Biomater. Sci. Polymer Edn.
Publisher
Volume/issue/page 6, 463-479
Publication date 1994/05
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